Thank you for buying Posters or Postcards!

12. How does my poster purchase fund cancer research?
For every Hand-Signed Poster sold on the network we will donate 10.00 Euros to cancer research and for every Unsigned Poster 1.00 Euro, irrespective of the type of poster we sell. GoArt Postcards are now being sold with either 10 or 20 Euro-cents donated to cancer research, see postcards for details. After you make your Poster or Postcard purchase GoArt will forward the money onto a separate bank account earmarked for funding. Please Note that any customer wishing a refund for their unsigned poster will have a one 1.00 Euro fee deducted from their reimbursement, or in the case of limited edition hand-signed posters 10,00 Euros. A refund for Postcards is at all times possible though minus the 10 or 20 cent donation fee. For fine art Posters, Postcards and ArtCards where the artist has written a personal or special message a refund is not possible. Sponsoring is an on going aim of the artist though may stop at anytime without prior warning or notice.


12 (A) How is my poster or postcard money used in fighting cancer?
We are pleased to announce that Garry Orriss is funding the work of Prof. Dr. Susanne Schlisio of The Ludwig Institute for Cancer Research at the Karolinska Institute in Stockholm Sweden for her teams work into molecular and cellular basis tumour biology. Dr. Schlisio studies the key development of pheochromocytomas or ("pheos"). Pheos arise from the same primitive cells that give rise to parts of the nervous system. These primitive cells are sometimes referred to as 'neural crest' cells. Some families are at high risk for developing Pheos (in the adrenals) or Paragangliomas (outside the adrenals) because they have alterations in specific genes (VHL, SDH, NF1). Professor Schlisio and her team discovered that these genes play essential roles in determining whether neural crest cells live or die. They have also discovered that by activating EglN3 that it kills pheo cells and other neural crest-derived tumors. In contrast EglN3 does not cause cell death in any other type of cancer that they have examined to date. This is important because when these genes are mutated, neural crest cells that should have died as part of the normal development of the fetus escape their death sentence and go on to cause tumor development later in life. Professor Schlisio has also proved that a gene called 'EglN3' (pronounced "eggelin3") plays a critical role in this process and that EglN3 plays a role in the decision between life and death for neural crest tumors such as Pheos. EglN3 promotes the death of neural crest cells whereas inhibiting EglN3 function has the opposite effect. In short, Professor Schlisio and her team have discovered new ways into understanding the mechanisms by which EglN3 causes cell death. This understanding could in time allow doctors to cause pheo cells to die in patients and shrink existing tumours as well as preventing new pheos. From all of us at the GoArt-Network we congratulate Prof. Dr. Susanne Schlisio and her Teams work into pioneering important scientific breakthroughs into cancer research and wish them the best for future discoveries. If you would also like to support cutting edge technology into cancer research in the field of molecular biology why not donate directly to the laboratory? Donations are tax deductible! Prof. Schlisio and her Team are well known in the scientific community for developing special techniques within molecular biology and combining these with genetics and biochemistry. For further details on sponsoring visit our Terms and Conditions Agreement.
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Selected Publications with links to the relevant medical journals or publications

U.S. National Library of Medicine National Institutes of Health August 19, 2009
Schlisio S. Neuronal Apoptosis by Prolyl Hydroxylation: Implication in Nervous System Tumors and the Warburg Conundrum J Cell Mol Med. [Published online ahead of print]

REUTERS April 2, 2008
$1 Million in New Grants Awarded to Further Melanoma Research in 2008 -- Dr. Susanne Schlisio, Dana-Farber Cancer Institute, "Neuronal Apoptosis by the Prolyl Hydroxylase EglN3: Oxygen Sensing and Cancer"

MRF Announces 2008 Named Research Grants April 21, 2008
Dr. Susanne Schlisio, Dana Farber Cancer Institute:
Award in Memory of Don Aronow

Genes & Development April 2008 1;22(7):884-93
The Kinesin Gene KIF1B Acts Downstream of EglN3 to Induce Apoptosis and is a Potential 1p36 Tumor Suppressor. 1;22(7):884-93 Schlisio Susanne, Kenchappa RS, Vredeveld LCW, George RE, Stewart R, Shahriari K , Greulich H, Nguyen VN, Dahia PL, Pomeroy S, Maris JM, Look TA, Meyerson M, Peeper DS, Carter BD and Kaelin WG.

Nature Cell Biology. 2008 Febuary 24
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Schlisio Susanne, Young AP, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S and Kaelin WG.

PRESS RELEASE Research sponsored by Garry Orriss and 2008
Prof. Dr. Susanne Schlisio has funding from the worldwide sales of Garry Orriss Art und posters and postcards.

Research sponsored by VHLFA. 2006-2007
Dr. Susanne Schlisio, Cancer Research Institute. Boston. Key developments in the development of pheochromocytomas (pheos.)

Cancer Cell - Science Direct,
Volume 8, Issue 2 155-167, 1 August 2005 Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer.

Genes & Development December 1, 2004
A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription 18: 2941-2951; doi:10.1101/gad.1239304

EMBO, 21: 5775-5786, 2002
Interaction of YY1 with E2F's, mediated by RYBP, provides a mechanism for specificity of E2F function. [PubMed - indexed for MEDLINE]

FEMS Microbiology Letters Volume 174, 1999 Pages 117 - 123
The Bacillus subtilis regulator protein SpoIIE shares functional and structural similarities with eukaryotic protein phosphatases 2C

Susanne Schlisio, recipient of the German Academic Exchange Service (DAAD) scholarship to undertake the research project at the University of Oxford, England. Sept. 1997


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